Wanted to share these steps that just worked to resolve the re-detection issue. In my case it seems to have been caused by an old version of the PCIe driver being loaded underneath the new DriverKit driver.

1- Uninstall DriverKit driver by dragging RME Thunderbolt Settings.app to trash.

2- Uninstall remnants of old driver manually per instructions in the UFX+ user manual by removing:

/Applications/RME Thunderbolt Settings
/Library/Extensions/RMEPCleAudio.kext
/Users/username/Library/Preferences/de.rme-audio.RMEThunderboltSettings.plist
/Library/LaunchAgents/de.rme-audio.RMEPCIeAgent.plist

Reboot.

3- However even after these steps, Under System Report > Extensions, still saw RMEPCIe driver 1.22 running. Why?!
System Report tells me the kext is located at /Library/StagedExtensions/Library/Extensions/RMEPCIeAudio.kext

“Staged Extensions” which I believe is a macos cache for SIP approved extensions, stores a copy of the kext that is still being loaded!

Clear the staged extensions cache with this command:
sudo kextcache --clear-staging

Reboot, and no longer seeing the RME PCIe 1.22 driver in System Report > Extensions. Yay!

4- Reinstall DriverKit UFX+ thunderbolt driver v1.03. However, not seeing an “allow” button in Security preferences this time. I reboot anyways. On reboot, still not seeing the driver appear, so I wonder if it got trapped in limbo.

5- Reboot into recovery mode  (on M1, shut down machine and hold down power button while booting).
Open terminal, and run:
kmutil trigger-panic-medic --volume-root /Volumes/Macintosh\ HD/

Reboot.

6- On boot, Security preferences asks me to re-approve all system extensions and reboot. I oblige.

7- FINALLY, RME Thunderbolt Settings is launching on login and subsequent reboots.

This was on MacOS Monterey, 12.6.3, M1 Pro.

I have been trying to make my newly purchased RME Digiface Dante work. After following the quoted instructions I could make it work on my M1 Mac Studio, however, on the M1 MacBook Air the Totalmix window still won't show me the mixer after going through all of these steps multiple times. During the last step I still get this message:

I have followed all the previous steps, so, I don't get why there is still an active Kernel Extension. Does anyone have any further hints? I get that this is a thread for the UFX interface, but exactly the same steps helped me with my interface as well, so, I ask here.

edit: I actually got it working now after following said instructions for the 4th time. This time I disabled SIP during the whole procedure. Then I got the window to allow security settings for the RME USB device. It may be related to my disabling of SIP or it was just a coincidence.

Driver download links in this thread:
https://forum.rme-audio.de/viewtopic.php?id=38691

- Powering off UFX+ does not exit de.rme-audio.dkpci , it's still running (activity monitor)
- After powering it on again, a 2nd de.rme-audio.dkpci starts, and the unit is not detected.
- Just for testing, I powered it off/on a 3rd time, and a 3rd de.rme-audio.dkpci process was started, and UFX+ was still not detected.
- Only after *manually exiting all those 3 processes*, the UFX+ get detected after powering it on.

I hope this is helpful for RME engineers to solve this issue.

Then, I installed thunderbolt 123.pkg.  Then the "DSP" icon comes back with detection of UFX+.  But, there the driver is v1.22 written next to Firmware v111.  When I click "About HDSPe setting" button, it says "RME Thunderbolt Setting V1.23(1)". Is this the correct version?  I am very confused.  BTW.  I tried to reinstall the driver because newly purchased Dorico 5 Pro has audio engine error.  Some people reported same problem with RME BF old version of driver.

There are two downloads.

One is :

macOS 11/12 Thunderbolt driver for Fireface UFX+

The other one is :

macOS 11/12 Thunderbolt DriverKit driver for Fireface UFX+

What is the difference?  What should I install on my MBP?

what is your MacOS ?

One is :

macOS 11/12 Thunderbolt driver for Fireface UFX+

The other one is :

macOS 11/12 Thunderbolt DriverKit driver for Fireface UFX+

What is the difference?  What should I install on my MBP?

Any news regarding DK driver for UFX+ TB?

Currently using TB. But can switch to USB. Any words to the wiser?

Best,
Pål S.

Judging from previous entries, I think it's primarily an Intel iMac problem.

Ah, then perhaps it is a separate issue that I was experiencing on my M1 Pro. Don't mean to detract from the aforementioned re-detection issue.

Here's what I was experiencing: my UFX+ was recognized on first boot after installing the 1.03 TB driver, but on subsequent reboots "RME Thunderbolt Settings.app" would not launch even when the device was connected. Strangely, the CoreAudio driver was able to play sound out of the UFX+, just no control from RME Thunderbolt Settings.

Also, I am not suggesting disabling SIP. Mine is enabled. The command triggers a refresh of the SIP-approved drivers and kernel extensions which are then re-approved in System Preferences. (Documented elsewhere on this forum as well)

I don't think the 1.03 beta installer is removing all traces of the previous, kext-based PCIe driver.