Best would be if you could send more details, about what you did exactly.

Short summary from my side, this is how it runs here.
Except that I have the HDSPe MADI FX as main interface, but not long ago I also used the UFX III where it worked as well. Up to now it always worked, no matter whether TotalMix FX version 1.x or 2.x.

My 12Mic has firmware 2.0.1 (v176)
TotalMix FX 2.10 beta 3

On the 12Mic itself, it is important to configure MIDI control.
Press the "big knob": State -> Remote Control
Then press the 3rd button left of the screen for "MIDI"
Ensure that
- "MIDI Input" is set to "MADI Optical"
- "MIDI Output" is set to "MADI Optical"
- "Device ID" set to e.g. "1" (if this number has not been used already for other chained devices on the MADI bus)

Configure all devices (recording interface, 12Mic and any other chained madi device) to use the same
- MADI Format: 64ch
- MADI Frame: 96K frame
Where to find it?
- UFX III: in the driver settings dialog
- 12Mic: Web interface -> select "MADI optical" at the bottom and click the gear icon for MADI output settings.

Then in TotalMix FX
If you have multiple devices, select the instance for the UFX III at first.
Then in Options -> Mixer Settings (F3)
TAB "Auxdevice"

[assumed this is the 1st device and you start with MADI channel 1]

Channels (Bank): MADI 1-8
  Device 1
    Device Type: 12Mic 1-4
    Device-ID: 1
    MIDI In: UFX III Midi Port 3 (MADI optical)
    MIDI Out: UFX III Midi Port 3 (MADI optical)
  Device 2
    Device Type: 12Mic 5-8
    Device-ID: 1
    MIDI In: UFX III Midi Port 3 (MADI optical)
    MIDI Out: UFX III Midi Port 3 (MADI optical)

Channels (Bank): MADI 9-16
  Device 1
    Device Type: 12Mic 9-12
    Device-ID: 1
    MIDI In: UFX III Midi Port 3 (MADI optical)
    MIDI Out: UFX III Midi Port 3 (MADI optical)
  Device 2
    Device Type: None
    Device-ID: 0
    MIDI In: None
    MIDI Out: None

If you use Auxdevice, no other remote control program may run:
- no RME connector
- no MIDIremote (older solution)

Hi Ramses, I've done everything you listed, and checked many times.
I've scheduled a TemViewer call to sort it out.
Thanks for you willingness!
Vee

I could have a look at this remotely via TeamViewer if you want... Send me an email.

Hi Daniel,
I've sent an email few minutes ago.
Thanks very much,
Vee

Short summary from my side, this is how it runs here.
Except that I have the HDSPe MADI FX as main interface, but not long ago I also used the UFX III where it worked as well. Up to now it always worked, no matter whether TotalMix FX version 1.x or 2.x.

My 12Mic has firmware 2.0.1 (v176)
TotalMix FX 2.10 beta 3

On the 12Mic itself, it is important to configure MIDI control.
Press the "big knob": State -> Remote Control
Then press the 3rd button left of the screen for "MIDI"
Ensure that
- "MIDI Input" is set to "MADI Optical"
- "MIDI Output" is set to "MADI Optical"
- "Device ID" set to e.g. "1" (if this number has not been used already for other chained devices on the MADI bus)

Configure all devices (recording interface, 12Mic and any other chained madi device) to use the same
- MADI Format: 64ch
- MADI Frame: 96K frame
Where to find it?
- UFX III: in the driver settings dialog
- 12Mic: Web interface -> select "MADI optical" at the bottom and click the gear icon for MADI output settings.

Then in TotalMix FX
If you have multiple devices, select the instance for the UFX III at first.
Then in Options -> Mixer Settings (F3)
TAB "Auxdevice"

[assumed this is the 1st device and you start with MADI channel 1]

Channels (Bank): MADI 1-8
  Device 1
    Device Type: 12Mic 1-4
    Device-ID: 1
    MIDI In: UFX III Midi Port 3 (MADI optical)
    MIDI Out: UFX III Midi Port 3 (MADI optical)
  Device 2
    Device Type: 12Mic 5-8
    Device-ID: 1
    MIDI In: UFX III Midi Port 3 (MADI optical)
    MIDI Out: UFX III Midi Port 3 (MADI optical)

Channels (Bank): MADI 9-16
  Device 1
    Device Type: 12Mic 9-12
    Device-ID: 1
    MIDI In: UFX III Midi Port 3 (MADI optical)
    MIDI Out: UFX III Midi Port 3 (MADI optical)
  Device 2
    Device Type: None
    Device-ID: 0
    MIDI In: None
    MIDI Out: None

If you use Auxdevice, no other remote control program may run:
- no RME connector
- no MIDIremote (older solution)

On the 12 Mic Settings>Remote>MIDI>
you have to set Input and output either Coax or Optical

Done, mate.
I've read the manual several times and still haven't found any clue

The settings are the following:

First setting Madi 1 - 8

1.device 12Mic 1 - 4

2.device 12Mic 5 - 8

Second setting Madi 9 - 16

1.device 12Mic 9 - 12

2.device none

For the input and output port 3

Totalmix menu options: Enable MIDI control

Let me know if you need any further information.

Thanks very much!

12Mic firmware 2.0.1 (v176)
Connector 2.0.0