I just wanted to share here in case this helps someone.  I spent days troubleshooting my RME UFX III MIDI Ports not showing up in any DAW or application at all on Windows 11.  I tried Nuendo 14, Cubase 14, Studio One 6.5, Studio One v7 and Studio Pro 8.  I also tried BOME translator and several local apps that can see all of your inputs.

To solve this for me, RME recently put out a Firmware Update in February 2026.  I was one behind.  I flashed it successfully within say 5 minutes.

Reinstalled all the latest drivers.  A dialog came up and told me to choose between my UFX III settings or all of my TotalMix FX settings.  I decided to choose TotalMix FX since I know I spent a month setting it up and saving all my backups.

After doing the above which shouldn't take more than 10 minutes with reboots all of my ports finally appeared in every Windows application and DAW.

Have a great day!