I also assume that you are not using the RME ASIO driver in Adobe Audition.
According to Google, it supports ASIO drivers.

For Windows itself and audio applications without ASIO support, you might have missed creating the WDM device in the RME driver setting for the I/O port where your monitors are connected and making this device the default sound device in the Windows sound settings.

Some related info from a former posting; some parts might be of interest:
https://forum.rme-audio.de/viewtopic.ph … 33#p243233

In the Windows device manager, is the card listed as active audio device ?

You have installed all correct, the RME driver for windows is the ASIO driver.

But in the DAW you have to select it correctly too. There may be other drivers available, Direct Sound, WDM, ASIO, etc.
Select RME ASIO.

Ok, thank you very much, I'll try in another PCIe slot. Do you think I have to modify some PCIe parameter in the BIOS like "legacy" or similar? I had initially this doubt, because Windows and all other softwares see the soundcard without problems, but when I try to play a short movie or a sound file all become locked and I must close the software.
The motherboard I have is for servers and is extremely complex to set up.

;-) the motherboard is new, installed just 15 days ago, so I'm sure there's nothing dirty or with dust :-D

I already did it. I tried all possible initiatives to understand what cause might be.

But the card is working to some degree, tbe analog and even ADAT input signals seem to show up...

The Windows I have is the LTSC Enterprise and there's no problem: all the Supermicro drivers was installed without problems and the BIOS is the last version. I thought at some bios parameter like all PCIe slots set as "legacy" or similar, because the only one I changed was the boot from the installed graphic card instead of the included VGA, all the others are the default parameters and, I think, don't need to be modified. The strage phenomenon is that if I run Windows with the soundcard installed but without any driver all plays without problems (With no sound, obviously), when I install the drivers the soundcard is perfect, Windows sees it, but all softwares become locked when I try to play everything with an audio track (AIFF, WAV, Youtube videos, reels...).

And does come ADAT clocking signal into the card? What about set it to be clocked on internal clock first, just to check, if wrongly working clocking is not the source of problem....

And have you tried different PCIe slot, as MC has suggested you?

According to your screenshot, the card is set to be clocked by ADATin, not by WC.

So, your card is clocked by ADAT, not by WC.... And does the driver indicate, that it is locked to clock. That is clocking working OK?

Still, you could try to streamline the setup for a while (for testing purposes) and set internal clocking. And try, if it works that way, or not.

Yes, I have noticed 128 cores, 256 threads and 256 GB of RAM. (And the price used to be almost 12 000 USD.)

Quite a beast. Just one pitfall, it has ZEN 4c cores, which is AMD´s ´little´ core. Unlike Intel it is no so little, it is the same design like a big core, just with smaller cache (and maybe other small differences) and runs at lower clock.

So, it has lower singlethread performance than full cores.

https://www.techpowerup.com/cpu-specs/epyc-9754.c3257

SOLVED!!! Almost a month, yes, a month of trying to solve this problem, but my head is harder than a block of lead!
Now the AIO pro works fine, but... what was the problem? Now I'll make you laugh: I tried different slots, different settings, different operating systems, I changed the BIOS settings hundreds of times, but nothing worked. And, in the end... the problem was a speck of dust stuck between two soldered contacts on the North Bridge! I disassembled and cleaned the entire motherboard and discovered this tiny piece of dust. Once I cleaned and reassembled everything... everything was perfect! It was tough, very tough against this evil motherboard, but in the end I won the electronic war!