EDIT1: maybe check connecting via USB2 1st as MC from RME suggests in post #7 of this thread.
You might have to set UFX+ to USB2 mode if "AUTO" doesn't work, see manual how to perform this.
EDIT2: added to set windows to optimize for background services
EDIT3: resorted order of tests and renumbered: Inspection 1st, then 1st LatencyMon run. Then Changes one by one with brief review whether audio drops still occurr and whether LatencyMon values became better. Maybe you see positive changes, but usually the sum of all changes brings best results finally.
I think, if this would be a driver problem, then you should see more problems like this here on forum, but this is not the case.
Experience shows, that there are other issues more likely, like chipset issues (X99), driver issues, BIOS / Windows related settings.
Proposal, instead posting back and forth 20 times I give you now a list of points that you could check.
Please answer the questions and/or post results.
1. What other interface did you use before where you didn't have issues ?
2. Can you try the UFX+ on another PC just for testing ?
3. When or how often do these audio drops occur ?
4. is it reproducable, if yes how ?
5. Do audio drops occurr only when working with Cubase with the ASIO driver or also under Windows with the WDM drivers?
6. Is it somehow related to higher CPU / ASIO load ?
7. What sample rates / ASIO buffer sizes do you use ?
8. Do you use CPU hungry VST or VSTi (virtual instruments in your cubase project) ?
9. Are you browing the LAN or Internet when these drops occurr ?
10. Do you have WLAN enabled to access LAN / Internet or via Network Cable
11. Do you see CRC transport errors over USB3 (driver settings dialog)
12. If yes: Did you try another USB cable ? Did you try all other USB ports ?
Before doing changes to the system:
13. What does LatencyMon report on an otherwise not loaded / IDLE system if you let it run for 10 minutes ? The tool simulates a DAW load, therefore do not run any other application. Does it report something like that your system is not well suited for audio ? Please post the report on this forum.
After each of the following changes check individually, whether the situation improved. Repeat audio tests which triggered audio drops (see also #4) and look whether LatencyMon values become better. A smaller 3 Min run should be sufficient for that.
14. How many WDM devices (for Windows compatibility) do you have enabled in the RME driver, reduce to 1 device only for the speakers.
15. Is energy saving disabled in the BIOS ? I only know Intel BIOS, on AMD BIOS the names could be different. Google for that. Most important to disable C-States, T-States, P-states. Sometimes you need to disable something called speedstep (Intel Calls this EIST, AMD might call it differently). In most cases you can keep TURBO on, as on my system this results in permanently 200MHz higher clock speed.
16. Do you use the High Performance Energy Profile ? If not please do.
17. Is CPU core parking disabled under Windows ? If not please do, you can use Bitsums Parkcontrol for that.
*18. Set Windows to optimize for background services, see also: https://www.tonstudio-forum.de/blog/ind … orderlich/
19. Final LatencyMon run like #13, did something improve ? The sum of each change might bring more than each individual change itself.
X10SRi-F, E5-1650v4, Win10Pro20H2, Cub11Pro, UFX+ (v0.9735), XTC, 12Mic, ADI-2 Pro FS R BE