Sorry for resurrecting an old thread.
I just got a new Madiface XT II that I wanted to use on Linux, hoping to get access to all available channels. I'm on MX Linux 25.3 (liquorix kernel v7.2.8) but I've also tried on Debian "Testing" (comes with kernel 7.2.8 as well). I'm using Reaper 7.81.
As mentioned here and in the other thread, not all altsets are working. Altsets 1 and 2 (52/54 vs. 100/102 channels) work at 44.1/48 when Reaper is using ALSA. Altset 3 (196/198 channels of I/O) produces garbled/distorted sound. At 88.2/96 only altset 1 provides clean sound.
I haven't been able to get native Jack to work at all. Pipewire (v1.6.9) and pipewire-jack stumbles over its 128 channel limit and doesn't even create a system audio device when set to the 'Pro Audio' profile. I'm getting a lot of the following in syslog:
2026-10-02T20:21:30.604913+02:00 xxxxxx pipewire[1434]: spa.alsa: hw:0,0c: Channels doesn't match (requested 128, got 196)
2026-10-02T20:21:30.612008+02:00 xxxxxx pipewire[1434]: spa.audioconvert: can't parse format Channel number out of range
2026-10-02T20:21:30.612091+02:00 xxxxxx pipewire[1434]: pw.node: (alsa_input.usb-RME_MADIface_XT__xxxxxxxxxxxxx-00.pro-input-0-512) suspended -> error (Start error: Channel number out of range)
Interestingly, recorded audio on altset 3 is clean without signs of distortion. The problem only seems to apply to playback.
Although 102 playback channels seem plenty, the Madiface's fixed internal channel layout for MADI 1 through 3 makes it impossible to use MADI 3 (coaxial) whose channels start at number 129 at 48k. Unfortunately, one of the devices I was planning to use over MADI does only provide coaxial. When using straight CC routing, access to AES I/O, Analog I/O or the Phones Out is also not possible because they start at channel #191. You have to sacrifice 3 MADI stereo pairs on MADI 1.
As mentioned before, here and in that other thread, RME might not be responsible for this but I wouldn't even know where to start looking for a way to report this to Linux kernel or ALSA 'people' 
I was missing the quality and reliability of RME gear since I've sold my UFX+ a few years ago (because of its limits with regards to Linux) and I was really looking forward to giving it another try but I'm kinda stuck now...
Any ideas on options going forward or things I could try?