Hi Ramo.

Welcome to the RME user forum, and happy new year.

With the UFX III, you got an excellent audio interface.

I have been using UFX III (and UFX, UFX+ in the past) for many years with Windows 7, 10 (also tried 11)
and with all different Cubase and now also Nuendo versions without any issue.

I think it's only a small problem, so let's see what we can find.

This means either you
1. enabled all WDM devices in driver settings or
2. are using the UFX III in Class-compliant mode.

To 1: not recommended, as it creates a high load during startup as all devices are being created dynamically.
Older computers had issues with it.
But why do you do this? On Windows, it is best to use ASIO drivers for audio applications.

To 2: CC mode is intended for iPAD or Linux. Ensure, that you use the normal USB3 mode:
        Check Options -> Hardware / Diagnostic -> Interface Mode: usually Auto but you can also enforce USB3

Do you know Cubase? After loading the proper RME MADIface ASIO driver, you need to add channels for inputs and outputs.
In Cubase 15 Pro, see Studio -> Audioconnections (F4).
You need to add buses for inputs and outputs.

Please provide screenshots of settings.
- RME driver settings
- Cubase (F4) Audio Connections
- and any screenshot that you regard as useful to show the problem.

I recommend
- Using Greenshot as a screenshot tool, as it's very easy to add arrows, boxes, and text to a screenshot to highlight the issue.
- Using Dropbox for placing screenshots, as you can't upload images directly to the forum.

How to post screenshots in the RME forum, see my short blog article on how to do that:
https://www.tonstudio-forum.de/blog/Ent … rum-EN-DE/

https://www.dropbox.com/scl/fi/vovx9hlp … 0&dl=0

https://www.dropbox.com/scl/fi/vbahzwzm … 3&dl=0

https://www.dropbox.com/scl/fi/bni2mrky … r&dl=0

I don't know how it can come to such a message on macOS.
Somebody else needs to take over, I have no Apple here.

https://www.dropbox.com/scl/fi/z0wnlvid … h&dl=1

Thank you Ramses anyway!
Maybe I need to send my new RME Fireface UFX3 back if it just doesnt work with Cubase

Of course it works with Cubase. But so far you did not provide anything that would clarify that the unit has correct drivers, is visible in the system and does at least simple things. Screenshots of Settings dialog and TotalMix might be helpful.

That said it looks like you forgot to set up all the Audio Connections (in menu Studio). Only 2 channels seem active, if at all.

And:
https://www.dropbox.com/scl/fi/p4k1dfmq … s&dl=0

How about Cubase Audio Connections (F4), Outputs?

It doesnt matter how many in/outputs I choose from F4 cause its doesnt play anything, the lights in the mixer deosnt move at all!
https://www.dropbox.com/scl/fi/irk8vtac … 4&dl=0

https://www.dropbox.com/scl/fi/moh2yous … k&dl=0

https://www.dropbox.com/scl/fi/v0harnas … m&dl=0

In the Fireface USB Settings dialog make clock-source internal not Madi input
Or do you have some Madi equipment connected ? In the Cubase settings you did set it to internal clock.source.
Also there is no WDM device selected as this is not available in Mac.

Cubase configuration is a mess
In Cubase connections you have created a lot of busses, some have nonsense outputs
A stereo bus with output ports phones and analog makes no sense.

Delete all busses
Set up one new bus correctly
Stereo output Left / Right assigned to output ports 1/2
Save configuration and restart Cubase, check if the assigned ports are correct
Also select another audio device internal speakers then reselect the UFX, reboot computer

Why is clock-source Madi optical ?

Your answer has nothing to do with the clock-source in question

Make clock-source internal

in the Fireface USB Settings dialog

Yes, I tried this already before and now again, still silent, still nothing in mixer!

https://www.dropbox.com/scl/fi/n18p672c … 4&dl=0

Without proper clock settings you might get clock issues over time (clicks, ..) it doesn't explain that "nothing works".
But you should simply set it proper.

Yes, I tried already all different settings, which one is most proper!? I can ty it agan

My last pic is this exactly!

I have Cubase 11!
Is that possible it has some old drivers there, or....?
I just tried the Garage band and looks like everything works there!
(just afraid to buy Cubase 15-if still some error is somewhere with my Steinberg settings or...?)

No need to buy. You can get demo versions of Cubase or any other DAW like Reaper.

Another idea just in case something would be wrong with your Cubase Settings.
I assume there is a folder with Cubase preferences / settings like in Windows.
Can you exit Cubase, rename this folder and restart Cubase.
Then configure everything from scratch (driver selection, adding buses to the inputs and outputs) and re-test.

Audio from Cubase you should see in TM FX middle row, SW playbacks and
needs to be routed to the HW output where your monitors are connected to.
In TM FX (submix mode):
1. in the bottom row select the hardware output where your monitors are connected to (usually HW Output AN 1/2)
2. in the middle row: move the fader of SW Playback AN 1/2 (where you see the metering from cubase) to 0 dB.

Yes! It was! (checked it already yesterday)

And the interface works fine with system audio
No need to check the driver extension ?

MacOS system preferences / General / startup items and extensions
scroll down to driver extensions and hit the small i-icon right side
a switch may reveal

this:
https://www.dropbox.com/scl/fi/qmd0pyci … p&dl=0

+1  idea from Ramses
try CubasePro 15 demo version for free

Macintosh HD / Library / Application Support / Steinberg

You can delete or rename the entire folder to get to a point of brand new Cubase start

Glad you find out.
Maybe it is also a problem of Cubase 11 with Tahoe.
There was a lot of development in the MacOs history since Cubase 11 release.