If you can get a UFX+ in good condition, why not.
Thunderbolt as additional transport gives you an option in case it's needed.
Yes, MADI is a good thing.
If you get an RME device used then the price is usually 65-80% of street price (depending on age and condition).
If the unit is in good condition I would say the price is very well.
[ EDIT: just see Matthias Carstens remark. Maybe price is even too well; check the unit as good as you can.
I just had an eBay deal. Wonderful Sonnet Pro card which costed €160 years ago (not manufacured anymore)
and now used for €40. One of the four USB3 ports was damaged; I had to return it.
All the efforts that you do not want with such a purchase. ]
The differences between UFX+ and UFX III you can read here in my blog:
https://www.tonstudio-forum.de/blog/ent … ufx-en-de/
If you want to get an idea of how UFX+ and UFX III compare in terms of RTL, then check this blog article.
https://www.tonstudio-forum.de/blog/ent … cts-en-de/
The differences between those products or between USB3 and Thunderbolt are not that high as you can see.
Under Windows, the Thunderbolt driver will give you additionally the pitch feature, which is not available under the USB3 driver. I am not sure whether this is also the case under macOS. I never required it, but it's simply an additional feature that you can make use of if needed.
I upgraded from UFX+ to UFX III mainly for the reason to optimize converter latency as I am using my UFX III as a parallel effect loop for my Marshall amp to add FX parallel not serial. In such a scenario I wanted the lowest converter latency possible even if the difference is low.
BR Ramses - HDSPe MADI FX, M-1620 Pro D, 12Mic, UFX III, ADI-2 Pro FS R BE, Nuendo 15, Win10 IoT Ent