Currently available interfaces that work in linux

Almost all ( in class compliant mode )

Not the hdsp cards
Not the Madiface USB

Pick one interface that looks interesting for you and check the user manual for "class compliant"

In some cases you need a Windows or Mac computer to switch ON CC-mode in the interface, afterwards connect the interface to a Linux computer and use the audio inputs and outputs of the interface directly.

Older HDSP cards work pretty much out of the box, like Multiface I & II with the pcmcia, pci or pcie adapter card. Run hdspconf and hdspmixer. It comes with alsa-tools-gui in any standard distro.
The AIO PRO is a different beast and needs hdspeconf which needs to be compiled.
This is what I personally ran succesfully

True.
Thats pretty new, the new firmware with class-compliant-mode was released in January this year.

What is that ?

Thanks

Summarize

The Digiface AVB is the only RME interface not to use on Linux

All other actual  RME interfaces can be used on Linux

Old Firewire interfaces FF400 and FF800 can not run on Linux

Hdsp card needs some special software as mentioned here :
https://forum.rme-audio.de/viewtopic.ph … 34#p251734

Instead of Totalmix one can use Reaper Linux to route all monitoring needed.

Just to chime in on this, I'm using a Fireface 800 plugged into a PCIe Firewire card on Linux, and it's working fine across the system as well as for using Reaper. There are a few guides out there I followed, and I went down a rabbithole of troubleshooting things and trying to overcomplicate my setup before eventually just going with .. the simplest approach. The baseline ALSA audio subsystem, no jack, no libffado stuff. The Firewire maintainer for Linux through 2029 is active and very knowledgeable, and these devices have been so well documented that they do work totally well. You have to set up a couple of pipewire and wireplumber rules, but it's doable, just annoying to wrap your head around if you also happen to be new to Linux as I was.

It's possible through using your huge brain or sic'ing your agent of choice onto the source code for libffado to engineer tools that'll let you hot-flash (e.g. apply settings to the mixer while the system's running) to control input/output levels, phantom power and the like as well; we're in an age where you can roll your own TotalMix replacement if you want to. To be clear, ffado-mixer basically already *is* this, but to use that tool you need to have jack/libffado claim the audio stack instead of the snd_fireface kernel, and I found that wasn't working reliably for my system, so it was necessary to try to build some stuff from the ground up.

I'm happy to share the specifics but just know that generally no one cares to see anyone else's slopcoded TotalMix TUI / CLI tool or whatever. But don't give up on your old hardware! It (and the fantastic driver support that I now miss) is what makes RME so fantastic.