I just updated to the latest driver, and it seems like the mouse movements and clicks are causing pops and clicking.
This was never a problem before this latest 3.067 update.

Windows 7 64 bit
hardware rev. 1.70

This has nothing to do with my audio gear so I won't list it.

My firewire cable is shielded and ferrite coils. balanced outputs to speakers.

This is a driver issue, as I said, only happened after update.