I have reported before that the driver installer executable rmeinstaller.exe does not work properly. I have used it on three different Windows 10  Pro 64 bit machines, all of which are updated to the latest version ( 1803 ). The installer hangs after the first screen. The task continues to run without any CPU activity and after waiting for approximately 60 seconds appears to continue and finish correctly. However after a reboot the icon for the control tool is not present. To get around this is was necessary to go to the
C:\Users\%username%\AppData\Local\Temp\rme directory and run or rerun dpinst64.exe. Incidentally I also tried running as administrator but that made no difference.

On the particular machine I was building today ( core -I7 but with a fairly old socket LGA 1366 motherboard) there was a further problem even then because the ASIO drivers were not working. In Audacity ( built with ASIO support ) no ASIO drivers were even detected. In Foobar 2000 the output could be set to Madiface ASIO but when play was pressed it said that the driver could not be loaded. I checked a number of things but eventually found that I had to disable the Realtek HD Audio ( Realtek ALC889 codec) by switching off the on board audio device in BIOS. Not the first time I have found that Realtek drivers break ASIO ( and not only the RME ASIO drivers).