yes at the expense that you have lost all flexibility of TM FX to create individual monitor / phones submixes, that can even include audio from the HW inputs with near-zero latency.
Then all of your routing will have the full RTL through USB/TB.
There is an alternative, the reset mixer menue in TM FX contains an entry that does the same routing as DAW mode has.
By this you have the same routing as DAW mode with one keystroke and then additionally have some more flexibility in cases where needed.
1. Options -> Reset Mix -> Full Reset
2. Options -> Reset Mix -> Straight Playback
BR Ramses - UFX III, 12Mic, XTC, ADI-2 Pro FS R BE, RayDAT, X10SRi-F, E5-1680v4, Win10Pro22H2, Cub13