Due to your special configuration - separate USB’s for in and out- I cannot recommend a specific setup.
In general with USB ADI-2 Pro tends to use the USB clock, so most setups should be fine.
You can check with various “Modes” for ADI-2 Pro.
To switch the Mode unplug the USB-cable to make it valid.
My typical clock test signal is a high frequency sinewave, like e.g. 19 kHz.
Do your setup, record the sinewave, then listen to the recording (not too loud to prevent blown tweeters).
If the clock was asynchronous during recording somewhere in the signal path, you will notice repeated clicks.
No clicks - everything OK, clocks in sync.