Geizhals.de shows 13 variants of B650/B650E mainboard. Which one is it exactly?

BTW, which version of Windows do you have?

> Mobo doesn't recognize the card in any pcie slots.

What do you mean by doesn't recognize?
Do you see the card in Windows device manager?

Are you sure that the card is properly seated in the PCIe slots?

Did you install the RME ASIO driver? As of today: https://rme-audio.de/downloads/driver_hdsp_win_447.zip

Does the fut tools discover the card after installation of the ASIO driver and a reboot?
https://rme-audio.de/downloads/fut_wdm_dspe.zip

It is strange that even the device manager does not recognize the new hardware, even if a driver is not installed.
I would expect at least a device entry with the yellow symbol indicating that a driver is missing.

> The newest driver from rme website does not install properly.
What does this mean, is there an error message or how do you come to this conclusion?

Did you check whether the PCIe card is properly seated in the PCIe slot? Maybe some pins have no contact.

This could happen if the end of the PCIe card's bracket does not properly fit into the "slot cut-out" or "bracket slot".
If this is the case, it helps to bend the rear bracket of the PCIe card a little and carefully.
Just a little and only if this is the root cause.

Do you have another PC to check whether the card is being recognized there, working at all?

Nope device manager doesn't recognize any hardware at all. Never had any problems connecting a pcie card before. It's a used card from thomann. Hopefully its not broken or damaged.

There is a popup asking if the installer worked properly. I can't recall the exact wording.

The older esi pcie card works in every pci socket.

Got a new card from thomann, it worked instantly.