Hey there, hope I can help many of people experiencing latency problems with soundcards.
I purchased the Babyface but had huge problems with latency and was unable to set buffer size below 1024 in order to get rid of cracks, pops and dropouts, which was ridiculous especially because I have a top high end PC (I7 980 6c, Win 7 64...)
I mainly work with Sonar 8.5, as a DAW but knew it wasn't the cause, for I had problems outside of it. I feared an incompatibility problem with my Nvidia Quadro FX 4800, or my Cintiq 21 UX, or whatever... (spent the whole night figuring it out)
Then I downloaded dpclat (http://www.thesycon.de/deu/latency_check.shtml) to check about my latency and saw that I had huge red peaks every second (and a message saying I'd be unable to use the PC in real time). Obviously tried to deactivate one by one everything as adviced, but no success! And suddenly, I found what caused the bug:
Simply a small utility software installed with my Asus motherboard: PC Probe II. (scans temperature inside the PC to adjust automatically fans rotation speed). Right-clicked on the icon on the bottom right of windows and quitted, everything runs perfectly!!! )))))))
Now I run the Babyface at 64 samples buffer size in Sonar 8.5 on Win 7 64 bits (a lot of huge VST plugins and all you can imagine...) without any latency delay, and with a crystal clear sound. Actually the best I've ever heard!!!
You guys at RME are amazing, so, many thanks to everyone involved, your products rock!
This is the first time I can play piano or my guitars in Guitar Rig 4 in perfect real time. RME products are definitely the must-have! And the Babyface is awesome!!! (the Totalmix software is just a bit tricky to comprehend at the beginning, not intuitive at all, but I don't really use it, doing everything in Sonar. I'm sure it could be simpler, but, don't want to be killjoy there, cos' I'm so thrilled with my new baby!) Es ist wunderbar !!!
Anyway, if this helped you, thanks to share the information, for I've spent the night reading forums and seen many people with problems like mine, and found no one who thought about this kind of small utility software.