@ramses The link doesn't seem to work anymore.
I am interested in this as well.
I am using a UFX+ with a Macbook. I switch off all of my gear when I don't use it, but my laptop will be disconnected and simply sleep. However when I plug my UFX back in my laptop (after switching it back on) and I haven't touched TotalMix on my laptop in the meantime, I still get this message.
I never know whether to answer yes or no to the question about restoring settings, because I have no idea if my hardware settings changed by switching it off/on, or my laptop did something by unplugging the device, or something else... Everything should have stayed the same AFAIK.