Rualark wrote:ramses, thank you for your reply.
I use SSD for most of instruments. SSD and HDD do not seem to be an issue (see video results that I posted).
Do you mean that there is no solution to this problem? If I could use larger buffer up to 1 second, I think this would not be an issue. Is it possible with RME or other soundcards? I use M-Audio C400, it allows up to 4096 buffer, but it is also not enough for 56 virtual instruments.
Maybe try other USB card, which uses a more efficient driver model (MSI's), this needs a PCIe socket with 4 PCIe lanes:
Sonnet USB3-PRO-4PM-E
Smaller variant is available, but then 1 USB3 controller is being shared for all ports.
I know you only require USB2, but maybe the drivers are the tie breaker here in USB2 compat mode.
You could also check whether perhaps some of your virtual instruments need more resources than other.
Maybe its also related to the problem with 200ms audio hangs, see one of my articles.
You need to try try try .. something is wrong there, but most likely not the RME driver or interface.
I would do a Win7 parallel installation to be able to check out whether there you can see a difference to Win10.
Sorry, but its difficult to solve things like this, very time consuming, why some people buy turnkey systems.
BR Ramses - UFX III, 12Mic, XTC, ADI-2 Pro FS R BE, RayDAT, X10SRi-F, E5-1680v4, Win10Pro22H2, Cub13