@cyrano: you were quicker BTW .. does he really talk about an Apple computer ?
@hced: Yes you can do.
Loopback is only needed if you want to record audio from PC applications in your DAW,
otherwise your DAW can access every i/o port of your recording interface using the RME ASIO driver.
You can create loopback recording for every HW output / submix.
As soon as you enable Loopback on the submix, then you can record this submix on the corresponding input.
It's useful to use Output ports that are otherwise not required, in many cases the ADAT outputs are useful for that.
Especially if there is no preamp connected on ADAT in.
Then you have with one ADAT i/o port the possibility to create up to 4 stereo submixes for loopback recording as you like.
You need only to take care that you perform proper gain staging .. every new channel sums up.
But it's easy, simply adjust the Faders of the different SW playback channels (eventually also HW inputs)
and adjust the levels to each other that they do not overload the output and that the volume between them makes sense. Finally you can also create a fader group to adjust the volume for them all at once to not overload the output.
The only thing that could become challenging for you is Microphone Input via WDM drivers.
As far as I understood it's a limitation of the Microsoft Driver model.
You can get them only as stereo channel.
So it could happen that your headset mic connected to PC then of all sudden only plays only on the left channel.
Therefore I would try to use only Mics connected to the Recording Interface, there you do not have this issue.
BR Ramses - UFX III, 12Mic, XTC, ADI-2 Pro FS R BE, RayDAT, X10SRi-F, E5-1680v4, Win10Pro22H2, Cub13