You provide only very few information about your setup
- hardware (CPU, Memory, Mainboard, Graphic card)
- operating system (i.e. which exact version of Windows 10)
- what application are you using for audio playback
- does this application support ASIO and did you really select the RME ASIO driver
- what sample rate is in use for your audio content ? The usual 44.1/48 kHz or higher ?
- what USB cable you are using
- to which USB port you connect the ADI-2 DAC
Did you try a different USB cable ?
Did you try all USB ports on your computer ?
The USB ports that come from the chipset of your mainboard are usually the best.
I would try all USB2 and USB3 ports.
How is the CPU load on your computer when you playback audio ?
Which Energy Profile are you using (assuming you use Windows) ? Can you try full power for max performance ?
Are you browsing the internet when the pop appear ?
Do you use Wireless or do you have cabled network access ?
Did you check your system with tools like LatencyMon, how much headroom the CPU has, to transport audio.
If the kernel latency timer values are too high or have high spikes, then this means that a process or driver is consuming too much cpu time and blocks the CPU for too long. If the audio driver or process is on the same core, then audio loss is much likely. LatencyMon also supports you to find drivers, which run for too long.
BR Ramses - UFX III, 12Mic, XTC, ADI-2 Pro FS R BE, RayDAT, X10SRi-F, E5-1680v4, Win10Pro22H2, Cub13