Is that one of those crappy X99 motherboards?

Did you install the chipset (mainboard) and the graphic card's drivers?
Is it worse if you drag around windows?
Did you try another mouse?

I’ve tried wired and wireless mice. Both do the same thing. The latest nvidia drivers have been installed as well as the latest motherboard bios.  It stutters every time you move the mouse and  hover over things. It stutters if you open applications or scrolling over to the bar to open applications. It stutters whenever you hover the mouse.  It’s a monster machine with 64gb or ddr4 memory and top of the line i9 cpu. Not built by me but a dell workstation.

I’ll play wjth xhci things next I guess.  I have disabled Realtek almost completely with no effect.

Not only the Bios, but the chipset drivers need to be installed.
Usually supplied by the manufacturer of the mainoard.
Look into Dell's download section.

Windows generic drivers are often outdated or have bad performance.

My best guess is, an outdated, buggy USB chipset drivers causing this, see my post above.

Somehow posted, but it didnt show up.   I got this resolved.  no idea why it worked, but the suggestion to turn mouse trails on got rid of the problem.   Again - have no idea why, but that step solved my problem.

Long story short: You are experiencing a X99 + NVidia = USB drops bug that is reproducible on other X99 boards, too. Using a AMD GPU (driver) is another "workaround" to get rid of it, at least last time I tried (two years ago).

The reason why mouse-trails helped is that this turns off NVidia GPU hardware acceleration of the mouse-pointer drawing. Since you now are haunted by a mouse-trail you need to do the following to keep GPU acceleration disabled with no mouse-trail showing.

Open Regedit and navigate to the following registry key:

HKEY_CURRENT_USER\Control Panel\Mouse

Change the value of "MouseTrails" to -1

The side-effect of disabling hardware acceleration is that the mouse-pointer will now follow any software color shift originating from software like f.lux or Windows' own "Night Light" setting. This means that the mouse-pointer will also get that yellowish cast instead of staying blue/cold white. One could call this an advantage.

The drawback can be software like Teamviewer messing up its mouse-pointer drawing, maybe some games can also be affected.

With a normal mainboard I would also suggest to change the "XHCI hand-off" setting in BIOS/UEFI, but I suspect that your Dell BIOS does not expose that setting.

I only encountered the issue using the combination of x99 + NVidia drivers. Testing AMD drivers in comparison did not cause the problem. But that was two years ago, so things may change. My guess is that it is more of a BIOS issue than hardware one, but we cannot be certain.

When you apply the registry change I posted (-1 trails) you will get rid of all mouse-trails while still staying in software mouse-pointer drawing mode.

XHCI hand-off switching in BIOS may also be needed for some combinations of software, but your Dell BIOS might not even expose that setting.

Well, if AMD can do mouse-pointer GPU acceleration without breaking USB performance then at least it hints at NVidia doing something "different".

This isn't even a DPC Latency kind of issue, which makes it even odder.

Using several Dells by myself, i recommend to install >Dell Command | Update< from Dell. Had some trouble with my XPS13 sometimes and running this program helped. It checks the system and replaces old or damaged drivers and other software stuff.

I think part of it might be that X99 was one of the first USB 3.0 chipsets and there was something funky about the way it was implemented. I have 2 X99 boards and both of them have very unreliable USB ports. Keyboards and mice will sometimes randomly disconnect, external HDDs will not stay connected and I've had problems with many USB dacs from many different brands. The board's USB 2.0 ports are much more reliable than the 3.0 ports but they are also not super stable. It is possible that it has something to do with the Nvidia drivers since both of my x99 computers have Nvidia cards but I just upgraded to an AMD X570 board with an Nvidia 2080ti and I haven't had a single USB issue since.

Oh man.

Got the exact same issue with my FF800 (Firewire + TI chipset of course). Just recently upgraded from a 2012 NVidia GPU to a new one (GT710)[1].
And since then I started encountering this issue... for the first time in 8 years with my wonderful PC. so I assume it's in fact related.
I broadly updated everything (using a Driver Update app) but the problem persists... Pretty annoying that NVidia have the worst drivers on earth, unbelievable. I work for Steinberg and we've got plenty of issues with their unstable drivers.

I'm gonna try to turn on the mouse trail and then edit the registry if this drives me mad. Will report soon about my own findings.

[1] Btw, besides being unstable (cough cough) this GPU is very practical, allowing me to connect 4 HDMI ports simultaneously

Hi Everyone,

I've had X299 mainboard (Asus WS X299 Pro) for about 5 years, starting with i9-7940 cpu, now with i9-10980xe. Always has been on Nvidia GPU (1080Ti then 4080) and I also have one more PCIe slot occupied by 10 Gig ethernet and there are 2 M.2 SSDs.

I am also happy ADI-2 Pro SE owner since early/mid 2019, I regularly update firmware and have ZERO issues. So I'm not so sure this is a chipset issue. X299 has a decent USB3 support and I cannot say anything negative about this setup, at least based on my experience with lots of devices hangin on USB so far. I have 2 disk enclosures, logitech camera, ADI-2 Pro, external card reader, mouse, kb and monitor. This runs under Windows 10.

I 'fixed' the Alt + Tab problem - I noticed it only happened when switching between Windows (10) interface tabs (like Settings or Apps and Features) and everything else, so I figured it was (once again) a switch between non-GPU and GPU accelerated elements. Turning off the Hardware accelerated GPU scheduling solved it, although now I'm worried and suspicious about any piece of software that has such a function.

Still, my Fireface UCX, with similar drivers and the TotalMix works perfectly no matter what - would it be possible to use or get similar drivers for the ADI-2/4?