I think no :-)
TM FX's feature Layout Presets is only for the presentation in TM FX and to control whether OSC is active.
If your question is performance related:
See my review here, the full review text in the PDF file, 2nd link
https://www.tonstudio-forum.de/blog/ind … Pro-FS-BE/
See page 7, RME Driver Optimization:
PDF: https://www.tonstudio-forum.de/index.ph … l-v1-1-pdf
The driver automatically optimizes system resources.
To reduce the number of channels you could active the redundancy options in driver settings, see manual ch 18.1
With redundancy mode active the number of input channels is reduced to 66 (AES plus 1x MADI). The two other MADI ports serve as fail safe inputs and are used as soon as the signal on the 'Current MADI Input' fails. This setting is also a perfect
choice if the card is used as single MADI I/O, saving resources and providing simpler channel selection dialogs.
Mirror MADI1 Output to MADI2/3
This option provides a quick and simple solution to mirror the first MADI output to outputs 2 and 3. The outputs are reduced to 2+2+64 channels (AES, Phones and one MADI port). All the data routed and mixed to MADI port 1 is sent to MADI port 2/3 as well.
This option could also be used to use e.g. one or maybe even a second UFX+ as DURec recorder.
UFX+, 12Mic, XTC, ADI-2 Pro FS R BE, RayDAT, X10SRi-F, E5-1650v4, Win10Pro22H2, Cub12Pro