Topic: How I got rid of all glitches, and lost my computer, too
RME UFX+ and Lenovo E580 laptop, stock USB3 cable into USB3 port
occasional and unpredictable audio glitches (more frequently when recording at 88.2 kHz, less frequently when recording at 44.1 or 48 kHz). Tried the mouse trail trick, and that took away most glitches but not all.
It occurs only after a while, so it's no use try and record for a couple minutes: it won't glitch.
But when you record classical music concerts, it will glitch, sooner or later.
On the plus side: excellent mic preamps quality, so I did not want to settle for less.
First attempt: tried DURec and noticed it will never glitch. So I guess there may be a problem in the computer ports, because they are not designed for professional audio recording and so they might tend to go in "sleep mode" if they feel there's not enough data passing through. And two or four channels of standard resolution audio is not much data, actually, compared to HD media streams.
Second attempt: I got an Octamic XTC and noticed it glitches a lot less when recording from the USB2 out. Only occasional glitches, but still far from "no glitches whatsoever".
Third and final attempt: "Well, basically if I managed to put DURec in the Octamic XTC it would be all right!"
Enter Cymatic Audio uTrack24 with ADAT interface. ADAT interface works perfectly. I synced it to the Octamic XTC via standard clock cable. Cymatic uTrack24 is a well respected multitrack recorder that does only one thing: it record anything you feed into it on an external USB drive (it's also cheap, compared to RME products). The manual says it's better not using standard USB sticks, and use actual hard drives instead. So I went for an ultra-modern Samsung T7 1TB drive, guessing "the faster, the better".
Results: recorded 9 live concerts, two opera recitals and two historical plays in an empty theater so far, and not a single glitch. And I used only 1/4 of the hard drive. Sound quality subjectively feels better than USB2 or USB3. I suffered only a short data loss because one of the ADAT cables got loose, but I noticed, put it back in and everything went well.
Plus side: no operating system means no operating system acting up. System now is in a 3-space Gator rack (I left two half spaces for ventilation), it feels incredibly solid and performed flawlessy so far.
Minus side: I am selling my UFX+, lightly used in a non-smoker environment ;-)
So, my advice would be: computers and USB ports are potential trouble sources, try and record without a computer and everything will be fine.