Hello!
I can't confirm your question, but I don't see any reason why it wouldn't be compatible!
I 'm using the DF Usb with an X470 chipset and everything is rock solid.
Which MoBo are you using? Can you paste a link?
Generally, there are usb ports that come from the chipset and some that come directly from the CPU.
If someone is using dual nVme drives, dual graphic cards, wi-fi etc, some clutter may occur!
If you use the DF Usb on her own Usb bus and have your PC optimized for audio, I don't think that you would run into any issues!
Can't you send it back, if you order one and try?
Or you could wait for someone to confirm!
RME Gear: Digiface USB, HDSP 9632