I did this in the past with UFX which had Firewire 400 and USB2.
I wanted to work with firewire, but needed USB for firmware upgrades (which is not the case for the UFX+, there are flash update tools available for both, USB and thunderbolt).
There was a certain order that either USB or Firewire was quicker than the other driver.
I do not remember exactly anymore. Either I could change the settings on the UFX to use the one or the other
or I simply plugged or unplugged USB depening on whether I want to work with USB or Firewire.
And if I remember right, USB won if both was plugged.
Also with the UFX+ you can set interface mode to AUTO or a dedicated setting (USB3, USB2, ...).
But you can not expect, that the recording interface will work with both, USB or thunderbolt, either one or the other.
But what is the problem that you want to solve anyway ? Thunderbolt and USB3 deliver nearly equal performance, take what works best and as I said, flash update is possible through USB and Thunderbolt.
Thunderbolt has slightly lower RTL (but only very little). From driver/feature perspective the only advantage of Thunderbolt is, to have the pitch function in the driver, which doesn't work anymore in the new madiface usb driver.
Otherwise you only have certain "disadvantages" with thunderbolt, more expensive cables and max cable length is limited to 2m compared to 3m with USB3 which can be more problematic regarding the placement of PC and devices for recording.
BR Ramses - UFX III, 12Mic, XTC, ADI-2 Pro FS R BE, RayDAT, X10SRi-F, E5-1680v4, Win10Pro22H2, Cub13