Hello,
I am running Windows 10 pro with Pyramix.  SSL MADI is locking the RME UFX+. When Pyramix is launched, MIDI Out 1 and MIDI Out 2 blink.  I have never seen this before in the years of using this set up.  I just updated the RME driver to .9747.  That seems to have done the trick.  Very strange but I wanted to share the knowledge.  Could be that having used the MADI from a HORUS might have caused MIDI confusion, but I leave that thought on the MC's desk for further conversation....
Best.