I wouldn't get an interface with mainly AES ports, because then you are very limited to connect other devices.
Most preamps and AD/DA converter out there (also from RME) use ADAT or MADI.
AVB and Dante would also be possible, but then you wouldn't get a recording interface like the UFX with a veriety of ports and network has a certain complexity of its own and clock changes are not so easy.
So … Only MADI remains.
There you have basically two possibilities, if you want to have a card with a certain variety of ports:
a) UFX III - USB3 based
b) HDSPe MADI FX - PCIe based.

If you do not necessarily need 3 MADI buses, then I would recommend you to get an UFX III with one MADI bus.
Recommended, because this interface already gives you a good mix of ports, preamps and has useful options like DURec.

It has already been mentioned that an application can only load one ASIO driver.
So you can't mix the USB driver of the UFX and the HDSPe driver for the PCIe card.
It's also not possible to use UFX and UFX III together.
The UFX uses the old USB driver and the UFX III requires the newer MADIface driver which supports the required USB3 transport modes to be able to transport the number of channels reliably.