I'm a composer/producer/teacher who works with screen sharing 2-5x a day with different clients, students, or VideoRecordings. I've had my BabyFace Pro for 10+ years, and persisted with only TotalMix Loopback for five years or so, but had give in and purchase LoopBack by RA.
What horseofcourse is saying is true in my experience as well, but saying "Use TotalMix" does not solve every problem. Some notable problems TotalMix does not solve:
-MacOS QuickTime ScreenRecorder flattens the audio to Mono (taking it from Input 1). There seems to be no workaround outside of LoopBack-RogueAmoeba/BlackHole/SoundFlower
-Some clients insist on using Discord (video game devs) which rarely if ever recognizes my RME device input, and does not facilitate screensharing.
-Google Meet will not recognize TotalMix-Loopback playback (this is a Safari Issue, I believe. Chrome/Firefox will work)
-Zoom will recognize TotalMix-Loopback, but when "original sound for musicians" is engaged you it throws your mic channel hard left Analoge input 1, unless "COPY A->B settings" is engaged in Mic Settings for Channel 1. This can be quite limiting as is obvious, but it immediately negates the usefulness of Zoom Recordings, Mics/Inst running on the 2nd channel, among many other instances.
-I often do not want global sound being sent into my Totalmix-Loopback recordings. Recorded mixing sessions, collaborations, interviews, screen-sharing meetings, YT recordings -- they all can range from 15 minutes to 2+ hours. It is extremely unlikely that I will not receive a notification of any kind during this recording. One cannot always account for Do-not-disturb modes to catch all incoming notification sounds.
This is to say nothing of other applications that are regularly in-demand: Whatsapp, Messenger, Slack, Riverside, or any of the other which demand audio sharing permissions and are inconsistently buggy. Some are stand-alone, some are chromium based, some are browser based. I wish it were as simple as use Loopback-TotalMix, which I adore. I do not think the issue is with RME, but rather with the proliferation of options that clients tend to use. If you're working at home, or in a studio where you don't have to screenshare, record iterations, produce video content, mix options, or teach -- I think LoopBack-Totalmix is the perfect tool. It's a miracle, truly.
However, in my experience prospective clients do not remember if everything works perfectly, but they do remember that "this audio professional couldn't get his audio working during the interview". I even had a guy once suggest that I "click the little gear icon and change my microphone settings" to get the audio sharing to work.
LoopBack-RogueAmoeba solves all of these issues. Set it as the default microphone input globally for MacOS. Every platform works immediately, no hesitation, no configuring. Every application that isn't the DAW just see's a "LoopBack-RogueAmoeba" Microphone. Output varies depending on work type.
My DAW see's RME device for Input/Output (not System Setting or Loopback). Done, set forever and there are no issues on any platform.
USAGE TIP: Inside of the "Source" selection for LoopBack-RogueAmoeba remember to UNCHECK the "mute when capturing", and then you can set up a single loopback instance and leave it closed presumably forever.
It is possible that someone could setup exactly the same workflow using OBS' virtual microphone extension, route all of the source selections/window selections from OBS, program the recording and capture details to work reliably. I don't think that is news to anyone. Your mileage may vary, but over 10+ years using RME devices I've had enough issues with OBS in the past. Sometimes on MacOS RME devices won't even register, or they won't be gain controllable, or the routing will be hidden. It's open source software and while it can be very reliable, among the problems listed I have forgotten to turn it on once or twice while recording and that was enough for me to look for another option.
As anyone else who has posted or looked for information on this forum will tell you, RME devices are the best, TotalMix-RME is the absolute best. But as a software routing solution, it does not meet the demands of many modern professionals, who are at the whims of 3rd party audio-sharing solutions. How it is that TotalMix can solve 99% of all problems, and yet somehow cannot manage system stereo audio screen-recording, or other platform issues is beyond me, but the 100$ price tag for something I never have to think about or update, that provides total peace of mind for all applications is a no-brainer. Wish I didn't have to, but it's far and away the best and most reliable option.