I've found that if my Macbook Pro 3,1 goes through many cycles of sleeping and waking up with Disconnect enabled, after finally "Connecting" there is no audio and Totalmix no longer seems to work: although the meters show output it can't be assigned to output channels and all the output channel are dead.

The solution is to eject the Expresscard, quit the RME apps, and re-insert. Then all is normal again.

Like I said, a minor bug... FYI.