Just in case you have the same problem as me, I will tell you about my digital noise /60hz hum issues and resolution.
I have an RME 9652 connected to an ADA8000 8ch I/O via lightpipe.
Two analog outs (balanced XLR) of the ADA8000 were fed to the stereo input of my headphone amp (1/4" TRS). This is when I noticed a bad 60hz hum and also high pitch digital noise in my headphones that would change when I moved my mouse around.
I trouble shoot this prob for almost a week, trying to isolate problem and finaly found a solution.
It was my cable going from ADA8000 to HA4700 headphone amp.
The pin#1 of XLR must not be connected, only pin2=hot(+ve) and pin3=cold(-ve)
So:
XLR A pin1 ----> N/C
XLR A pin2 ----> 1/4A"TRS Tip
XLR A pin3 ----> 1/4A"TRS sleeve
XLR B pin1 ----> N/C
XLR B pin2 ----> 1/4A"TRS Ring
XLR B pin3 ----> 1/4A"TRS sleeve
After this mod to my cable, all digital noise is gone and 95% of 60hz hum is gone.
I realise this is not the same RME card/setup as you but my info may be able to help you in your setup.
Cheers and good luck
Mani