Hello JRT, thanks for the Reply. On my Mac, the problem solved itself, also had other construction sites. I had to reset my PRM and now it works again.

But then I had the same problem on my MacBook with a different operating system
MacBook Pro (15-inch, 2019)
MacOS 10.14.6

finally it works also on my MacBook.

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Here are a few remarks that might be useful for other people.

I Almost understood it. But I did not understood what I need to do to solve this Problem.

I know this security problem and appeared only after updating the driver 310. was asked for authorization and got the following note, with DeepL übersetzt:

"System Expansion Notice
At least one of your approved system enhancements is not compatible with future macOS versions. Contact "RME GmbH" for support."

Original German Alert:
"Systemerweiterungshinweis

Mindestens eine von dir genehmigte Systemerweiterungen sind mit zukünftigen macOS-Versionen nicht mehr kompatibel. Wende dich für Unterstützung an „RME GmbH“."

But now it works!

does not work

I installed it, rebooted, checked the Security Issue and it worked finally.

have the latest firmware installed