It does not support USB altsetting-3 extension of the UAC to transport DSD (which some other DACs do). Some vendors call that "native DSD".
But it support DSD over PCM (DOP). You can use USB to transport DOP to ADI-2 Pro/DAC on any operating system.
On the DAC side, Support DOP or USB altsetting-3 are equivalent. Either will send exactly the same DSD signal to the DAC chip.
There will be zero difference after decoding the USB packet.
Some OSes such as Mac or iOS, do not even support altsetting-3. In these cases, you have no choice but to use DOP.
The main drawback for not support altsetting-3 is, most hifi music players are not implemented correctly in DOP mode. When you pause/skip DSD music, it will output 0x0 (PCM silence) during that short duration instead of DSD silence (dsd marker bits + 0x69). ADI-2 will believe you switched to PCM mode and back to DSD, and cause a hiccup when you pause/skip.
If you are using a music player that is free from this bug, you're all good.