Please god tell me thats not true !
We have to start from scratch !
You have a RME Babyface audio interface and it is connected to your computer and Totalmix is working.
You have a pair of speakers, they are connected to the analog output 1/2 of the Babyface. correct ?
you have a headphone, it is connected to the headphone socket of the Babyface, correct ?
Can you choose the Babyface as system audio device inside the computer operating system ?
Can you choose the Babyface as audio output device inside the screenreader software ?
It is a big mess having onboard soundcard active together with external audio interface.
No wonder it is not working.
Best would be you take the other soundcard out of the computer.
And of course adat cabling from internal soundcard to the external interface is obsolete.
Some people reading this thread getting painful blue patterns on the face from hard face-palming.
You should take the telephone support from RME support or the Facebook call with Lightbox, he is a pro supporter.
I can give you further help here with long postings, no problem, when it is for Totalmix Babyface.
But in your actual system with internal soundcard, this is out of frame for me.
Prepare your informations.
What do you have and where is the target ?
Microphone, Babyface, computer, interface, all working together.
You want to do a Zoom session speaking thru your microphone into Zoom, listening yourself and the screenreader in the headphone, but the Zoom listener shall not receive the screenreader, only your voice.
From there we can can start with the Totalmix support. Checking the signals and routing them to the target.
After all it will work fine.
M1-Sequoia, Madiface Pro, Digiface USB, Babyface silver and blue