Why should it not be possible ? Do you fear mechanical "breakage" or are you worried about getting your used settings / routings ?

To recover your settings quickly on each of the PCs
a) In TotalMix FX there is an option in preferences to always initialize DSP device with TM FX settings
b) you can restore workspaces that you saved to your disk, containing all routing and placement on the screen
c) you can restore from quick workspace select with ALT+1, ALT+2, .. to get 1st, 2nd saved workspace

If you need to move an interface frequently I would change to an USB or TB based interfaces.
Although PCIe sockets are quite stable it has not been designed to be moved often, is not hot pluggable like USB and you need to be careful not to touch ICs not to destroy them with electrostatic (because an PCIe card has no case around it).

If you have MAC with thunderbolt you could make it easier/more robust by placing the card into an external case connected by thunderbolt, then you can plug the thunderbolt cable between your different Apple PCs.