Any USB cable will do as long as it doesn't violate specs (e.g. too long).
USB2 cable may be up to 5 m long.
It's not required to buy an expensive one, audiophile USB cables is marketing bullshit and every cable over €25 is a "crime".
But I would strongly suggest buying not the cheapest to have a good soldering/manufacturing quality and good plugs.
I made good experience with Lindy cables (be it USB2 or USB3) from their premium series.

To check for USB transport errors, you can open the RME driver settings.
Keep this window open, then a CRC check of transferred data will be performed and shown.
Only zero errors are acceptable.

The counters are in front of the CRC checks. Cc5, crc16, crc32 are simply the names of different types of CRC checks (no counter values).

If there are no transport errors then the issues are not over USB, then they are elsewhere.

If there are errors, try all other USB port, any USB3 or USB2 port will do or use a different USB cable.

USB is digital transfer of data .. how should it have an influence on reamping?
Once the analog signal has been converted into digital it's simply digital data that will be transferred lossless over USB and other digital interface ports like AES, ADAT, MADI, SPDIF ...

Counter question: do you have any doubts that your backup of data from PC to an USB disk is corrupted, because it is USB or because you used a cheap cable? As long as the cable is withing the specs and as long contacts are not broken and the plug no crap, you will have a solid PC backup even with the cheapest cable.

Is the same quality of data transfer when transferring digital audio data.
And with the CRC test which is built-in into the driver you can validate it.

Please provide a drawing of your setup and a screenshot of the relevant inputs and outputs in TM FX with reflevel settings visible and the submix selected towards amp input.

I am also doing such kind of things, but without issues.
I am using an UFX+ as well for things like creating a parallel effect loop, adding external FX (PCM81, PCM91).
I would guess you have an issue with levels if you use a high gain amp, but not with USB.

Older version of my setup here
https://www.tonstudio-forum.de/blog/Ent … -DURec-DE/

Now stereo setup with two Marshall combos and the two Lexicons, see drawing below.
Using it as well for re-amping, but only in rare cases. Mostly when looking for proper mic position at the amps (2x2).

Example recording:
https://www.tonstudio-forum.de/attachme … orrow-mp3/

Setup:

Guitar        PCM81  PCM91
   |               || ||       || ||
  Inst           || ||       || ||
*****UFX+*****************
   |                |           |               |
Guvnor         |           |               |
   |            EffSnd     EffRet     EffRet
   |                |           |               |
Marshall L---+         ComboL ComboR

Signal Chain:
Guitar---UFX+---Guvnor---Amp---EffSnd---UFX+---PCM81/91(100% Wet)---EffRet (Guit+FX)---ComboL/R

Can also be used for reamping, as I am plugging the Guitar into Instr Input and record the pure Guitar Signal as well.

Which sounds btw like this unprocessed (no Amp, no Amp VST) when using e.g. Jazz Guitar like in this case:
https://www.tonstudio-forum.de/attachme … -320b-mp3/

Reference Levels used at the UFX+:
Analog Out to Guvnor: -10 dBV (consumer level)
Amp Effect Send to Analog In: Lo Gain (max headroom, the highest insensitivity)
UFX+ to External Effects: +4 dBu
External Effects to UFX+: again Lo Gain (max headroom, the highest insensitivity)
UFX+ to Effect Return (Power Amp of Combo): -10 dBV (consumer Level)

I keep the levels low for silent recording, so that the amp doesn't get too loud.

At the end of the day .. invest €20 into shielded cable and try whether it makes a difference, no big deal.

But, can you pls send a sound example, so that its better understandable what and what amount of noise we talk about?

BTW, you posted faster than me, pls see above my setup and sound examples.