Been a long time user of the UFX over USB and it's been solid.  Thanks RME. 
Reaper has been working fine too. 
But recently there have been issues, where Reaper cannot see the ASIO driver for the UFX and fails on load.

This has either been caused by:
a) driver update v1245 - reverting to v1227 sems to have had a positive effect
b) SSD system drive replacement (cloned to a larger device using Clonezilla)

The SSD replacement meant adjusting the BIOS settings for USB, as the Asus X99 is USB3 throughout, and the Linux USB key needed BIOS changes.  Until that point, two Orico USB3 hubs connected MIDI devices, and the UFX was is on its own motherboard USB3 port.  This has worked flawlessly for a long time, although I seem to remember having to find a way to force USB2 rather than USB3 somehow, but it was a long time ago, and I do not remember how it was done.  Possibly EHCI or xHCI enable/disable in the BIOS?  If anyone knows more about this, by all means chime in.

Surprising that the UFX which is on a dedicated USB port is having ASIO driver problems.  Windows has no issue seeing it in Device Manager, and I can verify the driver, and use YouTube through it, etc.  WDM is assumed.  However, Reaper cannot detect the ASIO driver in its scanned list.  Sometimes when the UFX is switched on later than boot time, or reconnected, the USB insertion event does not light the blue LED, implying the driver has failed to load in Windows.

I labour this because it could very easily be USB BIOS settings, for sure, but reverting to v1227 of the driver has allowed Reaper to find the ASIO driver again.  Is there any issue with v1245 that could be colouring things?

Many thanks.

I have 8x WDM, 48kHz, 64samples, lastest UFX firmware, set up so the host cannot change the UFX settings - all never been an issue before.

EDIT: Driver v 1227, working
Updater reports: USB 361, Firewire 344, DSP 163, USB (class compliant) 29 - latest version flashed when v1245 was installed.  Dropped back to 1x WDM out temporarily.