The UFX III needs another driver, not the "old" USB driver for UC, UCX, etc .. but the MADIface driver, this one:
https://rme-audio.de/downloads/driver_m … _09843.zip
Which one did you install?
Do you see the UFX III in Windows device manager?
Do you use an USB Hub or is the device directly connected to the PC? If hub, then please connect it to the PC directly.
Did you try all USB3 ports? USB3 ports from (Intel/AMD) chipset are compatible and should always work. Also some additional 3rd party USB3 controller work well. Best is to try them all.
Did you try another USB3 cable or can you connect to another computer?
Which computer do you have? Laptop or desktop (model / mainboard, CPU, link to mainboard)?
Then it could be possible to check in parallel, which USB3 connections / USB controller are built-in.
What you could also check on the UFX III:
Check that "setup -> options -> Interface mode" is set to "Auto".
If that doesn't work for whatever reason try USB3.
Note, this can only be changed if USB is disconnected from the PC.
I also have an UFX III connected to Windows 10 22H2, this should be no problem at all.
Once the latest ASIO driver is installed successfully and the device is recognized by Windows you should also upgrade the Firmware to the latest version: https://rme-audio.de/downloads/fut_madiface_win.zip
BR Ramses - UFX III, 12Mic, XTC, ADI-2 Pro FS R BE, RayDAT, X10SRi-F, E5-1680v4, Win10Pro22H2, Cub13