1st thing before making changes to your system:
- Document BIOS Settings
- Make a reliable Backup of your system; IMHO the best backup program is Macrium Reflect Home.

I would propose to upgrade the mainboard BIOS and to look for special tuned DRAM timings. Better use the default timings.
I would deactivate not-used devices in the BIOS.

Then I would get a 2nd disk for a clean Windows installation.
Propose to use Rufus to create a boot image without the performance sucking Win11 kern isolation.
By this you can also leave out all the requirements for secure boot, tpm and online account.
To get rid of online account you should disconnect network during installation, additionally.

After Win11 installation install only the really required drivers and nothing more.
No update or other additional tools from the mainboard vendor.

Only stuff like:
- chipset driver (Intel or AMD)
- usb or network 3rd party drivers
- for the time being use the nVidia or AMD display driver as bundled with Win11

If you need network, LAN preferred, leave out Wireless for a moment, deactivate it if possible.

Check in your BIOS whether you use unusual settings. Some people use special timiings for their RAM.
Stick to the defaults here.

Make a disk image directly after installation and after driver installation, so that you can come back to that point at any time.
A good program for backup purposes is Macrium Reflect.

Finally install RME drivers.

RME drivers are very stable and well coded.
If there are such issues then I am pretty certain that there is something wrong on your system.
Either Hardware / BIOS or Windows related.
The question is what.

Therefore the proposal to use the latest BIOS, what the support guy of your mainboard most likely will tell you.
Then BIOS default settings and a review what needs to be changed for a recording system.
Disable C-States, C1N .. "the usual things to disable energy saving which has bad impact on DPC latency of your system".
And a vanilla installation and not installing any "crappy" tools from mainboard vendor or elsewhere which could impact the installation.

And .. b4 I forget to tell .. after new installation of OS and after every driver installation check with LatencyMon,
whether the DPC lacencies stay around the same on on IDLE system or whether they become significantly worse.
On top of your other BSOD problem you might install then a bad driver which might occupy CPU cores for too long.

https://www.computerbase.de/2024-08/ins … wei-jahre/
https://www.computerbase.de/2024-07/ins … s-ursache/

I mourn the old Xeons. Something like this now in new, affordable, reasonable performance and a server or workstation mainboard without "bling bling", not plastered with M.2, but with enough PCIe expansion sockets.
Extremely solidly designed systems. You simply fill them up with cards and it works.

https://www.tonstudio-forum.de/blog/Ent … mponenten/

M.2 you could also mount onto PCIe cards or simply use a NVMe card.
Then you have still enough PCIe sockets, just in case that you need them.
I saw mainboards which support up to four M.2 and for that purpose, they sacrificed many PCIe sockets.
I do not like this concept.
They should have invented something to connect M.2 cards on the case and then a cable to connect PCIe lanes to there.