If I may chime in... I have a similar problem I noticed today which is reproducible: Whenever I connect or disconnect a USB device, no matter which port (did try 3 different ports, not all), my audio does this: slight click/crackle - about 1.5s silence - slight click/crackle, the whole sequence repeating 2 times (so 3 times total).
It happened with 2 different USB devices. Power management manually turned off on all ports, and generally the power plan is set to highest performance. Latest Windows from 2 weeks ago, RME drivers just as old.
Also my Analog Rytm (which is not connected via USB, is only connected via Midi to my USB-powered Gm5x5x5 Midi interface) goes into play mode (stop button light goes out, first step lights up, but doesn't move to the second one), so I guess my Midi interface gets reset somehow. At the same time as the mentioned 3-click-sequence appears, in FL Studio the mouse pointer becomes a watch 3 times (like "loading..."; this only happens with the pointer in FL Studio, not in other Windows windows; the sound disappears also only in FL Studio, which is using the Raydat output. Windows sound is unaffected, be it routed through a Raydat output or the cheap HDMI sound output), while the event comment field (the line on the top left below the menu telling you what the function of buttons is when you mouse over) tells me that "midi devices have changed... refreshing...".
Btw I'm not using a babyface but a Raydat. But I doubt this is relevant because most issues I was facing with RME stuff I found discussed with all kinds of devices. Guess it's a driver issue. I also guess it has to do with USB, not any device in particular.
God I hate USB.
Oh btw I thought it might have to do with syncing, but I have Swissonic converters, one of which is the clock master. But then I would have expected the "sync" status in "input status" in the Hammerfall DSP settings window to flash for a second or so. But it doesn't do that (the master flashes very slightly regularly, but this happens all the time. I have no problems with the clock though, everything runs smooth).
I might also add that I am pretty sure that those clicks/crackles have happened before without me connecting or disconnecting any USB stuff (although I didn't have the power management turned off on every USB port then, just did that today), just much less frequent. The way I described above is really every time I disconnect or connect a USB device.
Anyway, for me this is only a slight annoyance, the general function of my Raydat is impeccable.
Still I would be happy about a fix...