Thanks for the reply.

Reinstalled the drivers.
Verified that RME Gmbh is allowed in the background per your suggestion.

The behaviour now is as follows:

Mac recognizes the Babyface Pro as a device.
When I send the output to the BabyFace Pro, I see the output LED's moving with the audio I am sending to it, so it looks like the device is connecting and working.

However, TotalMix FX remains disconnected.  I cant control the device through TotalMix.

Do I have some setting incorrect?  How do I get TotalMix to recognize the device so that I can control it?

Thanks again.

Is the unit in CC-mode ?

Press and hold the two buttons SELECT and DIM during power-up does flip normal-mode to CC-mode and back.
Try

The level meter LEDs on the front will show on startup the mode by big letters CC or PC.
You should use PC (normal-mode)

When the Fireface USB Settings app is working, then the driver is working and has contact to the interface, Totalmix should open and work.
Try again.

Please check this :

Click the i button and ensure it's enabled

It was the driver extension Waedi pointed out with the pink arrow.
When I clicked on the 'i' it brought up a dialog where I needed to turn it on.

It didnt occur to me to click on this as once I saw the RME Gmbh selected above it, I though all was good.

Anyway, this is what was missing.

Thanks to all that contributed in working this out.  Hopefully it will save others time down the road.

Another user pointed me recently into this.
I have no clue why this is not enabled automatic at a few users.
The most people just run the installer and all is fine.
As on my own computer.
I have to admit, since Monterey OS I have SIP disabled, never had an issue from this.
Someone in the forum long ago told me I shall not recommend to disable SIP this may be dangerous to the computer.

I think it's good for the computer as I keep control of what goes installed, I don't need all these Apples paranoid Security doors and enabling switches.
And a hidden switch behind an icon that is mysteriously a button nobody knows, I would delete the whole Security section from MacOS as soon as I own Apple.

Waedi, i think it was me…

I i still recommend not, never, ever to turn off SIP permanently.

Disabling SIP permanent => if you forget your MacBook in a train, f.ex:
- forget previos enabled DriveEncryption (FileVault)
- forget that any data stored on it is still safe
- prepare resetting every password/2fa/passkey which is saved on it elsewhere
- iCloud etc…

Yes, Apple tries to expand its monopol and power. Thats clear. And they try to nag the Users, Manufacturers, even the EU. Absolutly with it: Totaly BS, what Apple does here.

But regarding Security: Always a bad idea to disable it general just because sth nags…

It is like cutting the cables of your Airbag in your car because it has detected a malfunction, signalling it by the red light in Cockpit. Ok, if you have to go to „TÜV“ tomorrow. But afterwards we would try however make the Airbag 100% working again. At least, if our Kids are sitting in the car. Right?

I recommend this (old) but still very good article regarding SIP: https://eclecticlight.co/2019/06/19/wha … rn-it-off/