Noise and hum usually results from ground loops*, often introduced from an USB connection.
DPS-2 alone might not solve the basic problem.
Adding an Intona or Topping USB isolator breaks the ground loop.

* A ground loop is a closed loop, a closed ring of ground connections.

This means, every device involved has two, instead of only one, ground connection to each other device involved.

E.g. a typical chain:
1. A PC, connected to mains ground and USB ground ->
2. ADI-2/4 Pro SE connected to USB ground and audio line ground ->
3. A power amp connected to this same audio line ground and the same mains ground as the PC, which closes the loop.

This loop covers a certain area in the room and acts as a pick-up coil.
Every noisy, stray magnetic field, like from a mains transformer and noisy stuff from inside the PC, induces a round going noise current into all ground lines involved.

Single ended audio interconnects refer to ground as part of the audio path.
A noise current in the ground lines becomes audible, as the current across the resistance of the cables causes different noise voltage potentials in the devices.

From this insight two possible solutions result:
1. Break the loop at any position that is suited for, without introducing safety issues, e.g. with an USB isolator.
2. Or, use balanced audio interconnects throughout, they are immune as they don’t refer to the noise polluted ground lines.